An anime television series adaptation was announced in March 2018. The anime series is directed by Seiki Takuno and animated by Liden Films, with Takao Yoshioka written the scripts, Yūki Morimoto designed the characters and Masaru Yokoyama composed the music. The series aired from October 6 to December 22, 2018, during the Animeism programming block on MBS, TBS, BS-TBS. The series was streamed on Amazon Prime Video in Japan and markets other than China. The series' opening theme titled "Love With You" is performed by fripSide, and the ending theme titled "Itsuka Sekai ga Kawaru Made" (いつか世界が変わるまで lit. "Someday Until The World Changes") is performed by Riho Iida. The series ran for 12 episodes
Boarding School Juliet takes place at Dahlia Academy Boarding School where students come from two rivalling countries known as the "Nation of Touwa" and "Principality of West". The story follows Romio Inuzuka, the 1st Year Leader of the "Black Dog Dormitory". Romio has an unrequited love for Juliet Percia, the 1st Year Leader of the "White Cat Dormitory". Initially hesitant, Romio decides to confess his love and resolves to change the world if it meant staying by Juliet's side. Juliet, impressed by Romio's determination, accepts his love. However, now both Romio and Juliet must work hard to keep their relationship a secret from other dorm mates while trying to avoid trouble.
In Episode 12 of Science Fell In Love, So I Tried to Prove It, there is parodied reference to the anime featuring Juliet Persia and Romio Inuzuka but with a recolored and alternate design, though with the same art style as the anime.